Safety and tolerability in research refers to the potential risks and adverse effects that participants may experience when taking part in a study or clinical trial. Researchers must consider and carefully monitor the safety of participants throughout the duration of the study to ensure that any potential risks are minimized and that participants are not exposed to harm. Tolerability refers to how well participants are able to tolerate the interventions or treatments being tested, in terms of side effects, discomfort, or inconvenience. Overall, ensuring safety and tolerability in research is essential to protect the well-being of participants and maintain ethical standards in research practices.